Bonn scientists reverse 60 years of cellular aging in human cells

Researchers at the University Hospital of Bonn directly reprogrammed red blood cell precursors from an 80-year-old into neural stem cells. Epigenetic clocks showed roughly 60 years of rejuvenation after 50 days, with cells displaying an age signature under 20. The gradual process was tracked for over 100 days, offering a model to study aging mechanisms.

• Cells from an 80-year-old showed an epigenetic age under 20
• About 60 years of rejuvenation observed 50 days after reprogramming
• Blood precursors became neural stem cells without a pluripotent stage
• The gradual process was tracked for more than 100 days