Mayo Clinic reveals how "zombie" cells drive aging inflammation

Seven Mayo Clinic studies published in Nature journals detail how senescent "zombie" cells trigger chronic inflammation, including the role of mitochondrial dysfunction. Researchers developed the SenMayo gene set for identifying these cells and proposed IL-23R as a blood biomarker of aging. Experimental senolytics and a tomato compound improved outcomes in aged mice.

• The SenMayo gene set reliably identifies senescent cells across tissues
• Mitochondrial DNA and RNA leakage triggers immune-driven inflammation
• IL-23R proposed as a blood biomarker of biological aging
• Senolytics and a tomato compound improved cognition and frailty in old mice