NVIDIA debuts open protein design model RFD4-Proteina with UW Medicine

NVIDIA announced RFD4-Proteina, an open protein-design model built with the UW Medicine Institute for Protein Design, at GTC Berlin. The 435.6M-parameter model is released under BSD 3-Clause via BioNeMo and partner platforms, alongside a new adaptive radiotherapy collaboration with Siemens Healthineers.

• 435.6M parameters, FP32 weights at 1.74 GB, released under BSD 3-Clause license
• A 250-token design takes 5.0 s on an H200 in BF16, 2.8 s after compilation
• Model handles seven tasks including generation, motif scaffolding and antibody design
• Available via Hugging Face, Google Cloud, AWS, OpenAI, Anthropic and other partners