Direct AMPK Activation Extends Lifespan by Over 25% in Yeast, Worms and Flies

Researchers from MRC LMS, Imperial College London and the University of Cologne used compound 991 to directly activate the cellular energy sensor AMPK, extending lifespan in fission yeast, nematode worms and fruit flies by more than 25% in some cases. The study, published in Aging Cell, is the first demonstration that direct pharmacological AMPK targeting has longevity benefits in living organisms.

• Compound 991 activates AMPK directly, unlike indirect activators such as metformin and semaglutide
• Lifespan rose by over 25% in S. pombe yeast, C. elegans worms and Drosophila flies
• The effect across three distantly related species boosts confidence it may translate to mammals
• Direct AMPK activators have already been used safely in clinical trials for metabolic diseases