Brain Signal May Explain How Protein Restriction Extends Lifespan

Researchers at LSU's Pennington Biomedical propose that the brain coordinates the body's adaptation to protein restriction. The hormone FGF21 is required for protein restriction to affect lifespan, metabolism and food preferences, according to a perspective in Cell Metabolism.

• Perspective published in Cell Metabolism on August 17, 2026
• FGF21 is required for protein restriction to extend lifespan
• In fruit flies, gut signals shape food preference and longevity
• FGF21 responsiveness and metabolic shifts may serve as biomarkers