Scientists Identify 5 Hidden Subtypes of Liver Disease Affecting 30% of Adults

Mayo Clinic and Virginia Tech researchers identified five biologically distinct subtypes of MASLD linked to different disease pathways and health risks. The analysis combined genomic and clinical data from more than 4,600 patients and was published in Nature Communications.

• MASLD affects nearly 30% of adults worldwide
• Five subtypes carry different risks for heart disease, liver failure and cancer
• Analysis covered data from more than 4,600 patients
• Some subtypes are driven by inherited genetics rather than obesity and diabetes alone