Tirzepatide may activate calorie-burning brown fat, mouse study finds

A mouse study found that tirzepatide (Mounjaro/Zepbound) activates brown adipose tissue, which burns glucose and fat. The effect persisted when food intake was matched, suggesting metabolic benefits beyond appetite suppression.

• Tirzepatide targets both GIP and GLP-1 receptors
• In obese mice the drug activated brown adipose tissue
• Effect held when food intake matched control mice
• Brown fat activation linked to beneficial batokines