New brain-scanning tech revealed Christina Applegate's MS diagnosis was wrong

Actress Christina Applegate said her 2021 multiple sclerosis diagnosis was incorrect, after a new MRI comparison technology flagged the error. Studies suggest 15–18% of MS cases are misdiagnosed, and updated McDonald criteria plus the central vein sign biomarker are improving accuracy.

• Applegate learned of the error via new tech comparing her brain MRIs with other patients
• Roughly 15–18% of MS diagnoses are later found to be incorrect
• 2024 McDonald criteria updates cut diagnosis time from years to days or weeks
• The central vein sign biomarker helps distinguish MS from similar diseases