MIT reprograms immune cells inside the body to destroy cancer

MIT engineers used lipid nanoparticles carrying mRNA to reprogram about 80% of targeted NK cells directly inside mice, avoiding extraction and lab engineering. Five injections eradicated T-cell lymphoma in humanized mice, and a single injection reversed autoimmune hepatitis liver damage.

• About 80% of targeted NK cells reprogrammed in vivo
• Five nanoparticle injections eradicated T-cell lymphoma in mice
• A single injection reversed autoimmune hepatitis damage
• Three of five melanoma mice reached complete remission