Stanford's iISM microscope images living cells without fluorescent labels

Researchers at Stanford University have built Interferometric Image Scanning Microscopy (iISM), which resolves structures inside living cells at about 120 nm without fluorescent labels. The system combines interferometric scattering microscopy with array detectors from advanced confocal microscopes and needs less illumination, reducing photodamage.

• iISM reaches roughly 120 nm resolution without fluorescent labels
• Method combines interferometric scattering with array detectors
• Lower illumination power reduces photodamage to living cells
• Study published in Light: Science and Applications