Natural RNA modifications in archaea mirror those used in medicine

Researchers at the Weizmann Institute and the University of Regensburg found natural phosphorothioate modifications in the RNA backbone of archaea — the same chemistry used to stabilize RNA therapeutics. The findings were published in the journal Cell.

• Natural phosphorothioates found in archaeal RNA backbone
• Same modifications used to stabilize RNA therapeutics
• Writer machinery for these modifications identified
• Study published in the journal Cell