XtalPi unveils Kodexia, closed-loop AI platform for siRNA discovery

XtalPi launched Kodexia, described as the industry's first closed-loop siRNA discovery platform combining generative AI, biological modeling and automated experiments. The company disclosed six therapeutic programs; its lead IgA nephropathy candidate reached non-human primate efficacy data in seven months.

• Platform runs over 500 in vitro and 30 in vivo experiments weekly
• Molecular design efficiency nearly tripled versus conventional workflows
• Over 50% of first-round designs beat positive controls in vivo
• Lead IgA nephropathy program hit primate efficacy data in 7 months