MIT study finds keto diet raises small intestine cancer risk in mice

MIT research published in Nature found that a ketogenic diet increased small intestinal tumors in cancer-prone mice while suppressing tumors in the colon. The effect was driven by fatty acid oxidation and PPAR activation, not by ketone bodies such as BHB.

• Keto diet raised small intestinal tumor rates in mice
• The same diet suppressed tumors in the colon
• Fatty acid oxidation and PPARs, not ketones, drove the effect
• Ketone supplements would not reproduce either effect, authors say