Scientists pursue an "exercise pill" that mimics the benefits of working out

Researchers are mapping the molecular pathways through which physical activity improves health to develop drugs for people with frailty, disability or chronic illness. Cambrian Bio's ATX-304 already boosted metabolism and cut liver and belly fat in people with obesity and prediabetes, while Pelagos' compound made mice run longer without training.

• ATX-304 boosted metabolism and reduced liver and belly fat in people with obesity
• Mice given the Pelagos drug ran longer and farther without any exercise
• More than 90% of treatments entering human studies fail
• The FDA approves drugs for diseases, not wellness, says Thomas Burris