MSK scientists uncover dual role of 5-oxoETE in inflammation

Researchers at Memorial Sloan Kettering found that the molecule 5-oxoETE both recruits immune cells to infection sites and protects healthy tissue via NUDIX hydrolases. The Nature study solves a 30-year-old mystery and links the pathway to cancer, inflammatory bowel disease and asthma.

• 5-oxoETE triggers protection through NUDIX hydrolases that clear damaged DNA building blocks
• The DHRS7 gene producing the enzyme behind 5-oxoETE had been sought since 1992
• Disabling the OXER1 receptor in zebrafish caused intestinal inflammation without infection
• Mutations in DHRS7 and OXER1 are linked to some cancers, IBD and asthma