AI analyzed 150,000 Reddit posts about gray-market retatrutide

Researchers at the University of Pennsylvania used AI to analyze nearly 150,000 Reddit posts and comments from about 40,000 users claiming to take unapproved gray-market retatrutide. After excluding expected effects, increased appetite was the most reported symptom, alongside sleep disturbances, higher heart rate and muscle changes — a pattern that differs from Phase 2 trial results.

• About 150,000 posts from roughly 40,000 Reddit users were analyzed
• 7,823 users reported at least one classifiable symptom
• Increased appetite topped reports after excluding expected effects
• Retatrutide activates three receptors versus one for semaglutide