Scientists Find Major Gaps Between Blastoids and Real Human Embryos

University of Sydney researchers built a reference map from over 14,000 single-cell transcriptomes of human embryos and benchmarked blastoids grown with four leading protocols against it. None fully matched natural embryo biology, though some reproduced all three major lineages relatively well.

• Reference map built from 14,000+ single-cell embryo transcriptomes
• Blastoids from four international protocols were benchmarked
• No model fully matched natural human embryo biology
• Reference datasets and benchmarking tools are publicly available