Scientists shrank mice brains and replaced missing tissue with human organoids

Stanford researchers created genetically modified mice that develop only 2% of the brain cortex and transplanted human cerebral organoids into them. In 90% of cases the tissue engrafts and within several months occupies most of the free volume. The work is published in Nature.

• Mice lack most of the cortex and hippocampus
• Human organoids engraft in 90% of cases
• Tissue occupies most of the volume within several months
• Mice showed deficits in motor skills, memory and socialization